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As the body wants to keep calcium levels very stable, the extra calcium eventually finds storage where you do not want it! The timeframe for experiencing noticeable results may vary depending on individual factors such as baseline nutrient levels, overall health status, and lifestyle habits. Consistent use of quality supplements along with healthy lifestyle choices should contribute positively to overall well-being over time. Are there any specific brands that offer vegan-friendly options for vitamin D3 and K2 supplements? Want to learn more about vitamin D3 and K2? Get in touch with one of our expert Nutrition Advisors who are on hand to provide free, confidential advice. Dosage: Pay attention to the daily dose of vitamins D and K in the supplement you choose. Recommended doses vary depending on individual needs, so consulting with a healthcare professional can help determine an appropriate dosage. Heart Health Support: Both vitamins D3 and K2 play crucial roles in cardiovascular health. Vitamin D3 aids in regulating blood pressure levels, while vitamin K2 prevents calcium buildup in arteries, reducing the risk of heart disease.
Wu et al. performed a comparative study of vitamin K2-7 effect, isolated from cheonggukjang, with vitamin K2-4 and vitamin K1. The effect of all three vitamins was determined on mineralization and cell differentiation of the pre-osteoblastic cell line MC3T3-E1 obtained from neonatal mouse calvariae. Vitamin K2-7, vitamin K2-4 and vitamin K1 significantly enhanced activity of alkaline phosphatase (ALP) that resulted in bone formation; increased proliferation of osteoblastic cell line MC3T3-E1 was also reported. It was observed that vitamin K2-4 and K2-7 had comparatively more dynamic effect than vitamin K1; this suggested that vitamin K2 (K2-4 and K2-7) and vitamin K1 probably have different mechanisms for stimulation of mineralization of osteoblasts. Furthermore, the mRNA expression ratio of osteoprotegerin and RANKL was also upregulated after treatment with 10µM of vitamin K2 (K2-4 and K2-7) for 24h. This indicates that vitamin K has a potential role in suppression of osteoclast formation by upregulating mRNA expression ratio of osteoprotegerin and RANKL ( Wu et al., 2019). Vitamin D and K both work together to raise calcium levels in the body, which may or may not be good for all of you. The trouble with too much calcium is it sneaks up on you and has been linked to atherosclerosis. Calcium, in excess, can contribute to heart arrhythmias, muscle pain or cramps, insomnia as well as agitation. It is what binds with oxalates to form kidney stones. Every have one of those, or know someone? They say the pain of that is worse than childbirth!
Excessive intake of vitamin D3 can lead to toxicity, causing symptoms such as nausea, vomiting, weakness, and kidney problems.
But again, I don’t think it’s necessary to put into vitamin D formulas, and this is a controversial subject.Strengthening the heart muscle is a huge workout benefit not just to elite athletes, but for everyone. We all need healthy hearts! May Improve Dental Health I generally avoid calcium supplements unless a client has clinical osteoporosis, or a 1,25 OH vitamin D (active, calcitriol) measurement >80 pg/mL coupled with low vitamin D stores (<40ng/mL 25-OH vitamin D, calcidiol).
Scenarios #3-5 focus on increasing K2 need (D3 may still benefit from higher intakes too to optimize levels). In this scenario, the high 1,25 OH may be a reflection of low D3 status in the first place and the body is working harder to make sure it has enough calcium available to the body. The focus is still on D3 intake and a wellness intake of K2. I only use 10,000 IU when 25-OH vitamin D (calcidiol) levels are significantly low (<25 ng/mL) or the levels do not seem to be responding to lower intakes. Some individuals (like myself) carry genetic markers in the vitamin D receptor that reduce their ability to absorb and utilize D3. Vitamin K2-7 Supplementation: 45-500mcg/day, still a wellness range, but a stronger recommendation to include it with your D3 supplementation. SCENARIO #3I chose to carry Vitamin A D K Complete by Doctor Alex Supplements as a baseline supplement that optimizes levels of all three fat-soluble vitamins (5000 IU retinyl palmitate for Vitamin A, 5000 IU** D3 for vitamin D, and 500mcg of K2-7 all in one capsule) – which work together. For those separating intake I carry Vitamin D 5000IU and Micellized Vitamin A Drops. Calcium should go to your bones. But if left undirected, it can end up in your soft tissue, instead. This causes vascular calcification (a hardening of the tissues) that can lead to bone spurs, liver and kidney stones, stiff blood vessels, cardiovascular disease, and major cardiac events. Antibiotics are commonly prescribed to treat bacterial infections. Unfortunately, they don’t just eliminate bad bacteria. They also kill off the flourishing colonies of beneficial bacteria that our bodies need to maintain optimal health. At this time, there haven’t been enough studies to establish a definitive correlation on the effects of K2 on dental health. But scientists have made some reasonable conclusions. The addition of K to a D formula doesn’t cost very much more for the maker to do it. I looked into it because I’m a supplement maker myself. It’s a slight increase, very very inexpensive to add to a vitamin D formula. Again, I’ve looked into this very thing because I thought for a micro-second to offer this combo supplement like my competitors do! I have received so many questions about why I don’t offer it.
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