2nd Edition, The Nemechek Protocol for Autism and Developmental Disorders: A How-To Guide For Restoring Neurological Function

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Well, around day 8 of the Nemechek protocol, I noticed that my lymph nodes weren’t swelling as bad after eating! Granted, it’s only a small difference, but there definitely IS a difference. I can’t tell you how much that means to me to have hope of eating normally again! One limitation to this study is that the molecular pathways that play a role in ASD are vast and intertwined. In the same sense, the therapeutic agents selected to intervene in these pathways will affect a wide array of systems throughout the body in addition to the targeted gene. It is, in fact, likely and possible that the interventions chosen to modulate the SHANK3 gene affected more than just the targeted gene. For example, zinc is a co-factor to many hundreds of reactions throughout the body [ 65]. In addition to stabilizing SHANK3, zinc supplementation will also affect many other protein pathways. Thus, the therapeutic benefit and full extent of the interventions cannot be entirely known. Molecular investigation sheds light on some aspects of how genes interact with these agents, but the sheer complexity of the human body requires more in-depth research and evaluation. Well, it’s been 3 months now, and there have been a lot of changes! At the beginning of September, I finally got a prescription for Rifaximin (Xifaxan). I had some pretty crazy “steroid rage” while on it, which is weird because it’s an antibiotic, but no other side effects other than that. Around Day 5 of taking the antibiotics for SIBO, I noticed a significant decrease in bloating. Now, I’m about 3 weeks post-Rifaximin, and I have little to no bloating anymore. Nemechek makes the claim autism is the result of vaccinations like Andrew Wakefield and J. F. Hardley, he claims another cause is "Small Intestine Bacterial Overgrowth" (SIBO), and that autism has nothing to do with genes. We have overwhelming evidence that proves his claims false, and we know there is no known cause of autism.

This variant is associated with lower enzymatic activity, specificity for substrate, and thermal stability. This decreases the ability to conjugate reduced glutathione with toxins for removal [ 61]. This time, I didn’t see the stark, immediate gains I did last time. By day 10 of the meds (last day), my SIBO symptoms had only improved a little. So what he is saying is that you can add to your diet, Extra Virgin Olive Oil, Omega 3 and Prebiotic - all of these things are natural. EVOO is medically proven to lower inflammation and good for general health, Omega 3 is proven for brain health and is naturally occuring in salmon - i do not like fish but I take Omega 3 to help my brain and prebiotics which is made from chicory. He is not asking you to take any of these things over the normal RDA. The genomic targets included in the CDS were identified by searching the published medical literature. The genomic targets were selected primarily through literature and database searches, including PubMed, MDPI, LitVar, and dbSNP. Information was gathered regarding SNP allelic frequencies. While many gene variants have been associated with autism, rare deleterious and pathogenic variants, such as those found in <1% of the population, were purposely not included. This exclusion of low-frequency and pathogenic variants was due to the idea that ASD can develop based on the combinatorial effects of multiple variants found in higher frequencies. Autism is where your brain develops differently to non-autistic people. It is not an illness and there is no cure.A small residual amount of damage will remain after each injury, and each new injury leaves residual damage upon the prior injury in a process referred to as cumulative brain injury. The abnormal neurological functioning from cumulative brain injury can occur slowly over time and or rapidly depending on the intensity of the brain injury. Damage to different portions of the brain will result in different outward symptoms such as ADHD, chronic anxiety or gait abnormalities. For people with celiac disease, gluten — a protein found in wheat, barley, and rye — causes an autoimmune response that damages our small intestine and can cause many other symptoms. The treatment is relatively simple, unless, of course, you’re French and baguette is your comfort food: you just stop eating gluten. There are no pills or transfusions or transplants to fix it — not yet, at least. It’s been an adjustment for me, but I feel better now. It’s funny. I remember reading testimonials from others who were 6 months to a year into it and thinking: The National Institute of Health and Care Excellence (NICE) will only recommend something if there is good evidence that it benefits autistic people. Patients who’ve experienced success with the protocol report that it has “reversed the symptoms” of autism in their children. The protocol is designed to reduce inflammation and bacterial overgrowth through the ingestion of olive oil and fish oil and the prebiotic inulin or, in older patients, the prescription antibiotic Rifaximin.

I also mentioned that I was waiting to weigh myself until I had been on the protocol for 1 month. I weighed myself today, and I haven’t lost a single pound the whole month! That’s great news for me as I’ve been losing weight dramatically each week, and I didn’t have any weight to spare to begin with. This variant results in increased IL1B, which can lead to neuroinflammation. This inflammation in the brain has been associated with decreased neurogenesis and increased stress, anxiety, and social interactions [ 57]. I am not a fan, however, of its claim that it can “reverse autism.” Its recommendations do not appear to stem from evidence-based science, relying on what seem to be anecdotes to make its case. I’m all for giving our kiddos supplements, but you don’t need to buy a book to do that. I’ve been on the Nemechek Protocol for about a month now. I’m not doing the Rifaximin as of now but that may change. So far, I’m still at the bottom dose of inulin at 1/8 tsp, 1 tsp of fish oil, and 1.5 tablespoons of extra virgin olive oil. I’ve attempted to increase the inulin dosage, but I get severe bloating when I do that.Right now, I’m enjoying feeling well. A few weeks ago, the Lord really helped me during a Sunday morning service, and I’m praising Him for what appears to be a “break” from all this. Now that you know this - can we review that is wrong? I told my doctor about this and whilst she wasn't raving about it she also didn't tell me i should not add EVOO or stop giving him omega 3, why? because even normal vitamins for kids contain omega 3 and there is nothing wrong in taking them. Prebiotics are naturally occurring in things like porridge and bananas - so nothing weird here either. Shank3 is a scaffolding protein that is densely associated with postsynaptic glutamatergic synapses and is an important part of the postsynaptic density (PSD), a specialized protein-dense structure attached to the postsynaptic membrane. It acts as a master organizer of the PSD because of its ability to interact with multiple key synaptic components, including glutamate receptor complexes, anchoring proteins, and the actin cytoskeleton [ 7]. SHANK3 is a critical orchestrator of frontocortical function. Disrupted connectivity of the prefrontal areas may underpin the socio-communicative impairments observed in SHANK3 mutation carriers [ 8]. I’m waiting to be on the protocol one month before I weigh myself again, but I think I’m finally starting to absorb nutrients again! How Long Does It Take the Nemechek Protocol to Work? If you suffer from unexplained bloating that you can’t seem to get rid of, it may be a hidden case of SIBO. I went from chronically bloated (like 7-months pregnant bloated…) to flat tummy in less than 2 months by simply following Dr. Nemechek’s advice. Keep reading to learn more!

If you haven’t already heard or read the research, the gut is often called our “second brain.” There is an undeniable link between gut health and brain health, which is why such incredible results can be had when you focus on restoring and balancing these two areas. And yet, 8 months have flown by. Now I’m reaping the benefits so many others have experienced – benefits that I had previously only dreamed of. A significant challenge with genomic medicine lies in translating an individual’s genomics into an action plan, a patient-centered personalized medicine response. To accomplish this, the first step is to understand how the gene variants identified in an individual’s genomic profile work on a molecular systems level. Then, it must be determined if there is a way to intervene in a genomically targeted fashion. Understanding the relevant molecular biology is paramount for developing clinical intervention strategies to target the variants’ function, pathways, and gene–gene interactions. The various cofactors, regulators, and enzymes that degrade encoded proteins can be considered for therapeutic intervention.Yes, actually. In all aspects of health, everyone is different, and every physical body responds differently. So there are some people who don’t improve on this protocol. They are far outweighed by those who do, but still, you should know that it doesn’t have a 100% success rate.